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Our ResearchIn the Center, faculty are using their expertise in the application of molecular tools to address problems of major significance in the nervous system. Using molecular and cellular approaches, researchers are working on problems such as neurodevelopment, axon pathfinding, transport mechanisms, neurodegeneration, neurogenesis, cell signaling, gene expression, and the pathobiology of Alzheimer’s disease. Gene discovery programs entail analysis of one of the three aforementioned animal models through a fusion of classical and molecular genetic approaches. Gene arrays, monoclonal antibody techniques, intracellular recordings, receptor analyses, real-time microscopy, and various anatomical methodologies are all being utilized to define molecular, cellular and sub-cellular features of the nervous system. These studies are leading to the creation of essential animal and biochemical models for basic processes and neurological disorders.
By understanding how neurotropic molecules work, researchers hope to get a better understanding of the unique and common features of diverse types of regenerative phenomena, and to provide the basis for true regeneration in the adult nervous system. The molecular bases of neurodegenerative diseases such as Alzheimer's disease and stroke as well as spinal cord injuries are areas of current investigation. Understanding of the basic mechanisms involved in the development and function of the nervous system and the abnormalities underlying disease conditions provide complementary information that will help find the solutions to neurological problems.
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